Current Treatment Protocols:

We have treated hundreds of patients with PAH with long-term intravenous prostacyclin, treprostinil, sildenafil, bosentan, sitaxsentan, ambrisentan, iloprost, and more. We accept referrals from all sources and welcome any interest or questions from health-care workers and from the general public.


LOOK

·     A trial of oral cicletanine to treat PAH is currently enrolling

·     A Phase 4 trial of ambrisentan for patients with PAH is ongoing.

·     A trial of a new oral prostacyclin drug (oral Remodulin) for patients with PAH will begin in 2010.

·     A trial adding a new endothelin antagonsist for patients already on PAH therapy is ongoing.

·     Exercise training (rehabilitation) trial: Click HERE for more info.

·     A trial for scleroderma patients who do not have PAH is ongoing. This study looks at ways to detecte pulmonary vascular disease in its earliest stages, possibly even before PAH begins

                  ...and more!



 

Summary of Research Trials at Harbor-UCLA

 

TRIAL

SPONSOR

PLACEBO

PRIMARY ENDPOINT

START DATE

Endothelin antagonist (added to sildenafil)

Actelion

Yes (1 in 2)

clinical worsening

Completed enrollment, December, 2009

Cicletanine

Gilead Sciences

Yes

6-minute walk

Ongoing

Oral Prostanoid

LungRx

yes

6-minute walk

Starts in 2010

Endothelin antagonsist

(ambrisentan)

Gilead Sciences

No

6-minute walk

Ongoing

Inhaled prostacyclin analogue

LungRx

Yes

6-minute walk

Enrollment complete, sorry

Guanylate cyclase activator (sGC)

Bayer

Yes

6-minute walk

Ongoing

Oral Remodulin (prostanoid)

United Therapeutics

Yes

6-minute walk

Starts in 2010

Exercise rehabilitation (see link above)

NIH/Harbor-UCLA

Yes

multiple

Ongoing

Scleroderma PAH screening

Harbor-UCLA

Yes

multiple

Ongoing

 

 



Conventional
PULMONARY ARTERIAL HYPERTENSION TREATMENT

       All patients are given an in-depth medical evaluation and counseled on the risks and benefits of prostacyclin in PAH.

       Initiation of prostacyclin takes approximately two days as an inpatient, and patients are usually ready to return to progressive activities upon discharge. While patients are hospitalized, their families and/or supporting members will be instructed on the use of prostacyclin, how to administer the drug, and what to do in case of an emergency.


For more information on any of the above trials, call our research coordinator, Joy at 310-222-3560




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